" 1 on 25 " is a document of information on an underestimated disease: the cystic fibrosis. This film proposes: a historic lighting and a medical explanation by the voice of a specialist; the fight of a grandmother, who decided to fight for her small son and all other patients through her association; patients' crossed portraits, as Lilian or Benoît, which live with this disease which involves a permanent adaptation in the situations of the everyday life.

The whole is given rhythm by underlining vox pop in which point the fellow is ignorant on the subject. Without ever falling in the pessimism, " 1 on 25 " is just like people whom we interviewed: simple, authentic, frank. This film is introduced by Sabrina, hyper-mediatized by the broadcast "Star Academy", who was anxious to bring to light these people of the shadow, got by the same disease as her.