A new scientific revolution is ongoing ! Our genome, this "great book of life " exultantly deciphered in the late 90's, brought few answers to our questioning.Cloned cats of different colors ? Real twins developing different pathologies ? The genome is in fact only a part of a much larger, and still unknown, frame named Epigenome by the scientists. Each of us have an Epigenome in constant evolution, according our way of life, our diet, our environment. Indeed this Epigenetic revolution deeply changes our understanding of the living. It opens a new point of view over aging and disease.